Des-Arg9-Bradykinin Peptide (High Purity)

Product Description

Price per 5 mg: $350
Catalog number: MDP0427
Name: Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe . AcOH . 3H2O
Other name(s): Des-Arg9-Bradykinin, Bk [Des-Arg9], [Des-Arg9]-Bradykinin, [Des-Arg9] Bradykinin, Des-Arg9 Bradykinin
Molecular Formula: C₄₄H₆₁N₁₁O₁₀
Molecular Mass: 904.02
CAS #: 15958-92-6
Storage Temperature: -20°C

Indication for Use:
This product if for Research Use Only (RUO). This product is not for administration to humans or animals. This product is not for human or veterinary diagnostic or therapeutic use.

Safety:
User must review the Material Safety Data Sheet (MSDS) provided with this product. In addition, this product should not be ingested, inhaled, swallowed or put in contact with eyes, skin or clothes.

About Des-Arg9-Bradykinin

Des-Arg(9)-bradykinin is an eight amino residues peptide consisting of the sequence Arg, Pro, Pro, Gly, Phe, Ser, Pro and Phe. This peptide is an analog of bradykinin without an Arg residue at position 9. This compound was found to act as a bradykinin receptor B2 agonist.

References

1: Eric J, Bkaily G, Bkaily GB, Volkov L, Gabra BH, Sirois P. Des-
Arg9-bradykinin increases intracellular Ca2+ in bronchoalveolar eosinophils from
ovalbumin-sensitized and -challenged mice. Eur J Pharmacol. 2003 Aug
15;475(1-3):129-37.

2: Farias NC, Feres T, Paiva AC, Paiva TB. Lys-[Leu8,des-Arg9]-bradykinin blocks
lipopolysaccharide-induced SHR aorta hyperpolarization by inhibition of Ca(++)-
and ATP-dependent K+ channels. Eur J Pharmacol. 2004 Sep 13;498(1-3):163-9.

3: Kaygısız Z, Kaygısız B, Kılınç E. The effect of Des-Arg9-bradykinin and
bradykinin-potentiating peptide C on isolated rat hearts. Acta Physiol Hung.
2013 Sep;100(3):280-8.

4: Sheikh IA, Kaplan AP. Studies of the digestion of bradykinin, Lys-bradykinin,
and des-Arg9-bradykinin by angiotensin converting enzyme. Biochem Pharmacol.
1986 Jun 15;35(12):1951-6.

5: Blais C Jr, Rouleau JL, Brown NJ, Lepage Y, Spence D, Munoz C, Friborg J,
Geadah D, Gervais N, Adam A. Serum metabolism of bradykinin and des-
Arg9-bradykinin in patients with angiotensin-converting enzyme inhibitor-
associated angioedema. Immunopharmacology. 1999 Sep;43(2-3):293-302.

6: Cabrini DA, Calixto JB. Characterization of des-Arg9-bradykinin-induced
contraction in guinea-pig gallbladder in vitro. Eur J Pharmacol. 1997 Jul
16;331(1):31-8.

7: Goldstein RH, Wall M. Activation of protein formation and cell division by
bradykinin and des-Arg9-bradykinin. J Biol Chem. 1984 Jul 25;259(14):9263-8.
PMID: 6430899.

8: Mahmudpour M, Roozbeh J, Keshavarz M, Farrokhi S, Nabipour I. COVID-19
cytokine storm: The anger of inflammation. Cytokine. 2020 Sep;133:155151.

9: More AS, Kim HM, Khang G, Hildebrandt T, Bernlöhr C, Doods H, Vanhoutte PM,
Wu D. Des-Arg9-bradykinin causes kinin B1 receptor mediated endothelium-
independent contractions in endotoxin-treated porcine coronary arteries.
Pharmacol Res. 2014 Dec;90:18-24.

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