[D-Pro2,D-Trp7,9]-Substance P

Product Description

[D-Pro2,D-Trp7,9]-Substance P
Catalog number: MDP0484
CAS Number: 117399-94-7
Sequence: Arg-D-Pro-Lys-Pro-Gln-Gln-D-Trp-Phe-D-Trp-Leu-Met-NH2
Amount: 500 ug
Molecular Weight: 1515.6 g/mol
Supplied as: Powder
Applications: molecular tool for various biochemical applications
Storage: -20 °C
WARNING: For in vitro Research Use Only. NOT for use on humans or animals.
Grade: Biotechnology grade. All products are highly pure.

References:
1: Matalińska J, Świć A, Lipiński P, Misicka A. Antiproliferative effects of [D-Pro2, D-Trp7,9]-Substance P and aprepitant on several cancer cell lines and their selectivity in comparison to normal cells Folia Neuropathol. 2020;58(3):237-244.
2: Edvinsson L, McCulloch J, Rosell S, Uddman R. Antagonism by (D-Pro2, D-Trp7,9)-substance P of the cerebrovascular dilatation induced by substance P Acta Physiol Scand. 1982 Dec;116(4):411-6.
3: Salt TE, De Vries GJ, Rodriguez RE, Cahusac PM, Morris R, Hill RG. Evaluation of (D-Pro2, D-Trp7,9)-substance P as an antagonist of substance P responses in the rat central nervous system Neurosci Lett. 1982 Jun 30;30(3):291-5.
4: Bossut D, Frenk H, Mayer DJ. Is substance P a primary afferent neurotransmitter for nociceptive input? IV. 2-Amino-5-phosphonovalerate (APV) and [D-Pro2,D-Trp7,9]-substance P exert different effects on behaviors induced by intrathecal substance P, strychnine and kainic acid Brain Res. 1988 Jul 12;455(2):247-53.
5: Fasmer OB, Post C. Behavioural responses induced by intrathecal injection of 5-hydroxytryptamine in mice are inhibited by a substance P antagonist, D-Pro2, D-Trp7,9-substance P Neuropharmacology. 1983 Dec;22(12A):1397-400.
6: Lembeck F, Amann R, Barthó L. Studies on effects of the substance P analogues [D-Pro2, D-Trp7,9]-substance P and [D-Arg1, D-Trp7,9, L-Leu11]-substance P not related to their antagonist action Naunyn Schmiedebergs Arch Pharmacol. 1986 Jul;333(3):290-3.
7: Rodriguez RE, Salt TE, Cahusac PM, Hill RG. The behavioural effects of intrathecally administered [D-PRO2, D-TRP7,9]-substance P, an analogue with presumed antagonist actions, in the rat Neuropharmacology. 1983 Feb;22(2):173-6.
8: Bobyock E, Barbieri EJ, Chernick WS. Effects of substance P and substance P antagonists on rat salivary secretion J Dent Res. 1986 Dec;65(12):1427-31.
9: Jensen RT, Jones SW, Lu YA, Xu JC, Folkers K, Gardner JD. Interaction of substance P antagonists with substance P receptors on dispersed pancreatic acini Biochim Biophys Acta. 1984 Jun 19;804(2):181-91.
10: Hökfelt T, Vincent S, Hellsten L, Rosell S, Folkers K, Markey K, Goldstein M, Cuello C. Immunohistochemical evidence for a “neurotoxic” action of (D-Pro2, D-Trp7,9)-substance P, an analogue with substance P antagonistic activity Acta Physiol Scand. 1981 Dec;113(4):571-3.

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