Cholesterol Sulfate (Highly Pure)

Product Description

Cholesterol Sulfate (Highly Pure)
Catalog number: B2013003
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 1 mg
Molecular Weight or Concentration: 488.7 g/mol
Supplied as: Lyophilized Powder
Applications: molecular tool for various biochemical applications
Storage: -20°C
Keywords: SCS, Sodium Cholesteryl Sulfate
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Xu D, Ma R, Ju Y, Song X, Niu B, Hong W, Wang R, Yang Q, Zhao Z, Zhang Y, Zheng Y, Bai Q, Lv M, Sun N, Li X. Cholesterol sulfate alleviates ulcerative colitis by promoting cholesterol biosynthesis in colonic epithelial cells Nat Commun. 2022 Jul 30;13(1):4428.
2: Strott CA, Higashi Y. Cholesterol sulfate in human physiology: what’s it all about? J Lipid Res. 2003 Jul;44(7):1268-78.
3: Chen Y, Zhu Y, Li X, Gao W, Zhen Z, Dong D, Huang B, Ma Z, Zhang A, Song X, Ma Y, Guo C, Zhang F, Huang Z. Cholesterol inhibits TCR signaling by directly restricting TCR-CD3 core tunnel motility Mol Cell. 2022 Apr 7;82(7):1278-1287.e5.
4: Lambeth JD, Xu XX. Cholesterol sulfate: a naturally-occurring inhibitor of cholesterol side-chain cleavage which functions at the level of intramitochondrial cholesterol translocation Endocr Res. 1989;15(1-2):85-99.
5: Elias PM, Williams ML, Choi EH, Feingold KR. Role of cholesterol sulfate in epidermal structure and function: lessons from X-linked ichthyosis Biochim Biophys Acta. 2014 Mar;1841(3):353-61.
6: Hu W, Zhao M, Lian J, Li D, Wen J, Tan J. Lithium Cholesterol Sulfate: A Novel and Potential Drug for Treating Alzheimer’s Disease and Autism Spectrum Disorder CNS Neurol Disord Drug Targets. 2022 Aug 25.
7: Zhang X, Deng D, Cui D, Liu Y, He S, Zhang H, Xie Y, Yu X, Yang S, Chen Y, Su Z. Cholesterol_Sulfate Exerts Protective Effect on Pancreatic β-Cells by Regulating β-Cell Mass and Insulin Secretion Front Pharmacol. 2022 Mar 4;13:840406.
8: Tatsuguchi T, Uruno T, Sugiura Y, Oisaki K, Takaya D, Sakata D, Izumi Y, Togo T, Hattori Y, Kunimura K, Sakurai T, Honma T, Bamba T, Nakamura M, Kanai M, Suematsu M, Fukui Y. Pharmacological intervention of cholesterol sulfate-mediated T cell exclusion promotes antitumor immunity Biochem Biophys Res Commun. 2022 Jun 18;609:183-188.
9: Fandrei F, Engberg O, Opálka L, Jančálková P, Pullmannová P, Steinhart M, Kováčik A, Vávrová K, Huster D. Cholesterol sulfate fluidizes the sterol fraction of the stratum corneum lipid phase and increases its permeability J Lipid Res. 2022 Mar;63(3):100177.
10: Kuroki T, Ikuta T, Kashiwagi M, Kawabe S, Ohba M, Huh N, Mizuno K, Ohno S, Yamada E, Chida K. Cholesterol sulfate, an activator of protein kinase C mediating squamous cell differentiation: a review Mutat Res. 2000 Apr;462(2-3):189-95.

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