α-Defensin-5 (Human)

Product Description

α-Defensin-5 (Human)
Catalog number: MDP0777
Amount: 0.1 mg
Name: Ala-Thr-Cys-Tyr-Cys-Arg-Thr-Gly-Arg-Cys-Ala-Thr-Arg-Glu-Ser-Leu-Ser-Gly-Val-Cys-Glu-Ile-Ser-Gly-Arg-Leu-Tyr-Arg-Leu-Cys-Cys-Arg (Disulfide bonds between Cys3-Cys31, Cys5-Cys20, and Cys10-Cys30)
Other name(s): α-Defensin-5 (Human)
Molecular Formula: C₁₄₄H₂₃₈N₅₀O₄₅S₆
Molecular Mass: 3582.1 g/mol
CAS #: 798569-33-2
Storage Temperature: -20℃

References:
1: Yang E, Shen J. The roles and functions of Paneth cells in Crohn’s disease: A critical review Cell Prolif. 2021 Jan;54(1):e12958.
2: M’Koma AE. Inflammatory Bowel Disease: Clinical Diagnosis and Surgical Treatment-Overview Medicina (Kaunas). 2022 Apr 21;58(5):567.
3: Luo G, Zhang J, Wang H, Sun Y, Cheng B, Xu Z, Zhang Y, Li H, Lu W, Nemeth E, Ganz T, Fang X. Human defensin-inspired discovery of peptidomimetic antibiotics Proc Natl Acad Sci U S A. 2022 Mar 8;119(10):e2117283119.
4: Liszt KI, Wang Q, Farhadipour M, Segers A, Thijs T, Nys L, Deleus E, Van der Schueren B, Gerner C, Neuditschko B, Ceulemans LJ, Lannoo M, Tack J, Depoortere I. Human intestinal bitter taste receptors regulate innate immune responses and metabolic regulators in obesity J Clin Invest. 2022 Feb 1;132(3):e144828.
5: Sugi Y, Takahashi K, Kurihara K, Nakano K, Kobayakawa T, Nakata K, Tsuda M, Hanazawa S, Hosono A, Kaminogawa S. α-Defensin 5 gene expression is regulated by gut microbial metabolites Biosci Biotechnol Biochem. 2017 Feb;81(2):242-248.
6: Williams AD, Korolkova OY, Sakwe AM, Geiger TM, James SD, Muldoon RL, Herline AJ, Goodwin JS, Izban MG, Washington MK, Smoot DT, Ballard BR, Gazouli M, M’Koma AE. Human alpha defensin 5 is a candidate biomarker to delineate inflammatory bowel disease PLoS One. 2017 Aug 17;12(8):e0179710.
7: Korbmacher M, Fischer S, Landenberger M, Papatheodorou P, Aktories K, Barth H. Human α-Defensin-5 Efficiently Neutralizes Clostridioides difficile Toxins TcdA, TcdB, and CDT Front Pharmacol. 2020 Aug 12;11:1204.
8: Yasuda G, Kobayashi M, Kubota A, Narumi K, Furugen A, Saito Y, Satoh T, Suzuki N, Iseki K. Analysis of α-Defensin 5 Secretion in Differentiated Caco-2 Cells: Comparison of Cell Bank Origin Biol Pharm Bull. 2021;44(2):275-278.
9: Liu Y, Xu T, Wang Q, Huang J, Zhu Y, Liu X, Liu R, Yang B, Zhou K. Vibrio cholerae senses human enteric α-defensin 5 through a CarSR two-component system to promote bacterial pathogenicity Commun Biol. 2022 Jun 8;5(1):559.
10: Qiao Q, Bai R, Song W, Gao H, Zhang M, Lu J, Hong M, Zhang X, Sun P, Zhang Q, Zhao P. Human α-defensin 5 suppressed colon cancer growth by targeting PI3K pathway Exp Cell Res. 2021 Oct 15;407(2):112809.

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