α-Conotoxin MI

Product Description

α-Conotoxin MI
Catalog number: MDP0512
CAS Number: 124447-81-0
Sequence: Gly-Arg-Cys-Cys-His-Pro-Ala-Cys-Gly-Lys-Asn-Tyr-Ser-Cys-NH2 (Disulfide bonds between Cys3-Cys8 and Cys4-Cys14)
Amount: 500 ug
Molecular Weight: 1493.6 g/mol
Supplied as: Powder
Applications: molecular tool for various biochemical applications
Storage: -20 °C
WARNING: For in vitro Research Use Only. NOT for use on humans or animals.
Grade: Biotechnology grade. All products are highly pure.

References:
1: Guo H, Deng B, Zhao L, Gao Y, Zhang X, Yang C, Zou B, Chen H, Sun M, Wang L, Jiao B. Programmed Aptamer Screening, Characterization, and Rapid Detection for α-Conotoxin MI Toxins (Basel). 2022 Oct 14;14(10):706.
2: Faragó Z, Mirzahosseini A, Horváth D, Pálla T, Horváth P, Perczel A, Noszál B. Solution Structure and Acid-Base Properties of Reduced α-Conotoxin MI Chem Biodivers. 2021 Oct;18(10):e2100464.
3: Zhang M, Yu S, Zhang X, Huang Q, Huang Y, Luo M, Wei Y, Chen W, Chen Z, Zhou X, Dai Q. A new protein-coupled antigen of α-conotoxin MI displays high immunogenicity and can produce antiserum with high detoxification activity Toxicon. 2022 Mar;208:53-61.
4: Luo S, McIntosh JM. Iodo-alpha-conotoxin MI selectively binds the alpha/delta subunit interface of muscle nicotinic acetylcholine receptors Biochemistry. 2004 Jun 1;43(21):6656-62.
5: Gray WR, Rivier JE, Galyean R, Cruz LJ, Olivera BM. Conotoxin MI. Disulfide bonding and conformational states J Biol Chem. 1983 Oct 25;258(20):12247-51.
6: Bren N, Sine SM. Hydrophobic pairwise interactions stabilize alpha-conotoxin MI in the muscle acetylcholine receptor binding site J Biol Chem. 2000 Apr 28;275(17):12692-700.
7: Papineni RV, Sanchez JU, Baksi K, Willcockson IU, Pedersen SE. Site-specific charge interactions of alpha-conotoxin MI with the nicotinic acetylcholine receptor J Biol Chem. 2001 Jun 29;276(26):23589-98.
8: Jacobsen RB, DelaCruz RG, Grose JH, McIntosh JM, Yoshikami D, Olivera BM. Critical residues influence the affinity and selectivity of alpha-conotoxin MI for nicotinic acetylcholine receptors Biochemistry. 1999 Oct 5;38(40):13310-5.
9: Gouda H, Yamazaki K, Hasegawa J, Kobayashi Y, Nishiuchi Y, Sakakibara S, Hirono S. Solution structure of alpha-conotoxin MI determined by 1H-NMR spectroscopy and molecular dynamics simulation with the explicit solvent water Biochim Biophys Acta. 1997 Dec 5;1343(2):327-34.
10: Kapono CA, Thapa P, Cabalteja CC, Guendisch D, Collier AC, Bingham JP. Conotoxin truncation as a post-translational modification to increase the pharmacological diversity within the milked venom of Conus magus Toxicon. 2013 Aug;70:170-8.

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