μ-Conotoxin GIIIB

Product Description

μ-Conotoxin GIIIB
Catalog number: MDP0605
CAS Number: 127060-75-7
Sequence: Arg-Asp-Cys-Cys-Thr-Hyp-Hyp-Arg-Lys-Cys-Lys-Asp-Arg-Arg-Cys-Lys-Hyp-Met-Lys-Cys-Cys-Ala-NH2 (Disulfide bonds between Cys3-Cys15, Cys4-Cys20, and Cys10-Cys21)
Amount: 500 ug
Molecular Weight: 2640 g/mol
Supplied as: Powder
Applications: molecular tool for various biochemical applications
Storage: -20 °C
WARNING: For in vitro Research Use Only. NOT for use on humans or animals.
Grade: Biotechnology grade. All products are highly pure.

References:
1: Hill JM, Alewood PF, Craik DJ. Three-dimensional solution structure of mu-conotoxin GIIIB, a specific blocker of skeletal muscle sodium channels Biochemistry. 1996 Jul 9;35(27):8824-35.
2: Sato K, Yamaguchi Y, Ishida Y, Ohizumi Y. Roles of basic amino acid residues in the activity of μ-conotoxin GIIIA and GIIIB, peptide blockers of muscle sodium channels Chem Biol Drug Des. 2015 Apr;85(4):488-93.
3: Li RA, Ennis IL, Vélez P, Tomaselli GF, Marbán E. Novel structural determinants of mu-conotoxin (GIIIB) block in rat skeletal muscle (mu1) Na+ channels J Biol Chem. 2000 Sep 8;275(36):27551-8.
4: Garcia N, Hernández P, Lanuza MA, Tomàs M, Cilleros-Mañé V, Just-Borràs L, Duran-Vigara M, Polishchuk A, Balanyà-Segura M, Tomàs J. Involvement of the Voltage-Gated Calcium Channels L- P/Q- and N-Types in Synapse Elimination During Neuromuscular Junction Development Mol Neurobiol. 2022 Jul;59(7):4044-4064.
5: Kubo S, Chino N, Watanabe TX, Kimura T, Sakakibara S. Solution synthesis of mu-conotoxin GIIIB: optimization of the oxidative folding reaction Pept Res. 1993 Mar-Apr;6(2):66-72.
6: Cummins TR, Aglieco F, Dib-Hajj SD. Critical molecular determinants of voltage-gated sodium channel sensitivity to mu-conotoxins GIIIA/B Mol Pharmacol. 2002 May;61(5):1192-201.
7: Torres NS. Activation of reverse Na(+)-Ca(2+) exchanger by skeletal Na(+) channel isoform increases excitation-contraction coupling efficiency in rabbit cardiomyocytes Am J Physiol Heart Circ Physiol. 2021 Feb 1;320(2):H593-H603.
8: Hurtado E, Cilleros V, Just L, Simó A, Nadal L, Tomàs M, Garcia N, Lanuza MA, Tomàs J. Synaptic Activity and Muscle Contraction Increases PDK1 and PKCβI Phosphorylation in the Presynaptic Membrane of the Neuromuscular Junction Front Mol Neurosci. 2017 Aug 25;10:270.
9: Uehara A, Moczydlowski E. Blocking mechanisms of batrachotoxin-activated Na channels in artificial bilayers Membr Biochem. 1986;6(2):111-47.
10: Leipold E, Ullrich F, Thiele M, Tietze AA, Terlau H, Imhof D, Heinemann SH. Subtype-specific block of voltage-gated K(+) channels by μ-conopeptides Biochem Biophys Res Commun. 2017 Jan 22;482(4):1135-1140.

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