Effect of genistein on IGF-1 and IGFBP-1 in young and aged female rat ovary.

A new interesting article has been published in J Anim Physiol Anim Nutr (Berl). 2019 May 30. doi: 10.1111/jpn.13131. and titled:

Effect of genistein on IGF-1 and IGFBP-1 in young and aged female rat ovary.

Authors of this article are:

Chi XX, Zhang T, Chu XL.

A summary of the article is shown below:

The objective of this study was to assess the effects of genistein (GEN) on expression of insulin-like growth factor 1 (IGF-1) and insulin-like growth factor binding protein 1 (IGFBP-1) in young and aged rat ovary. Forty young female Sprague Dawley (SD) rats (200 ± 20 g) and forty aged female SD rats (490 ± 20 g) were selected and according to weight, they were divided into the following five groups with eight animals in each: negative control group (NC), low-dose group (L), middle-dose group (M), high-dose group (H) and positive control group (PC). GEN group received GEN of 15, 30, 60 mg/kg respectively. It lasted 30 days. Concentrations of serum hormones, IGF-1 and IGFBP-1 were determined by enzyme-linked immunosorbent assay (ELISA). Gene and protein expressions of IGF-1 and IGFBP-1 were determined by real-time PCR and Western blot respectively. Compared with NC, GEN significantly increased oestradiol-17β(E2 ) level in aged rat, reduced luteinizing hormone (LH) level in young and aged rat. Serum levels of IGFBP-1 in young rats were significantly higher in GEN groups (p < 0.05). mRNA and protein expression levels of IGF-1 and IGFBP-1 were positively correlated with GEN dose. GEN could significantly reduce the ratio of IGF-1/IGFBP-1 of aged rats. Multivariate Cox regression analysis result showed IGF-1 and IGFBP-1 levels significantly correlated with GEN dose. We speculate that there is an association between the addition of GEN and expression of IGF-1 and IGFBP-1, and the relationship between them is different in young and aged rat.© 2019 Blackwell Verlag GmbH.
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This article is a good source of information and a good way to become familiar with topics such as: genistein; insulin-like growth factor 1; insulin-like growth factor binding protein 1; ovary; young and aged female rat.