POVPC (Highy Pure)

Product Description

POVPC (Highy Pure)
Catalog number: B2017906
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 1 mg
Molecular Weight or Concentration: 593.73
Supplied as: Powder
Applications: a molecular tool for various biochemical applications
Storage: -20°C
Keywords: 1-palmitoyl-2-(5′-oxo-valeroyl)-sn-glycero-3-phosphocholine
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Li Y, Zhang YX, Ning DS, Chen J, Li SX, Mo ZW, Peng YM, He SH, Chen YT, Zheng CJ, Gao JJ, Yuan HX, Ou JS, Ou ZJ. Simvastatin inhibits POVPC-mediated induction of endothelial-to-mesenchymal cell transition J Lipid Res. 2021;62:100066.
2: Lu L, Ye Y, Chen Y, Feng L, Huang J, Liang Q, Lan Z, Dong Q, Liu X, Li Y, Zhang X, Ou JS, Chen A, Yan J. Oxidized phospholipid POVPC contributes to vascular calcification by triggering ferroptosis of vascular smooth muscle cells FASEB J. 2024 Apr 15;38(7):e23592.
3: Yan FX, Li HM, Li SX, He SH, Dai WP, Li Y, Wang TT, Shi MM, Yuan HX, Xu Z, Zhou JG, Ning DS, Mo ZW, Ou ZJ, Ou JS. The oxidized phospholipid POVPC impairs endothelial function and vasodilation via uncoupling endothelial nitric oxide synthase J Mol Cell Cardiol. 2017 Nov;112:40-48.
4: Li Z, Luo Z, Shi X, Pang B, Ma Y, Jin J. The Levels of Oxidized Phospholipids in High-Density Lipoprotein During the Course of Sepsis and Their Prognostic Value Front Immunol. 2022 May 3;13:893929.
5: Pégorier S, Stengel D, Durand H, Croset M, Ninio E. Oxidized phospholipid: POVPC binds to platelet-activating-factor receptor on human macrophages. Implications in atherosclerosis Atherosclerosis. 2006 Oct;188(2):433-43.
6: Fruhwirth GO, Moumtzi A, Loidl A, Ingolic E, Hermetter A. The oxidized phospholipids POVPC and PGPC inhibit growth and induce apoptosis in vascular smooth muscle cells Biochim Biophys Acta. 2006 Sep;1761(9):1060-9.
7: Ademowo OS, Dias IHK, Diaz-Sanchez L, Sanchez-Aranguren L, Stahl W, Griffiths HR. Partial Mitigation of Oxidized Phospholipid-Mediated Mitochondrial Dysfunction in Neuronal Cells by Oxocarotenoids J Alzheimers Dis. 2020;74(1):113-126.
8: Ademowo OS, Dias HKI, Milic I, Devitt A, Moran R, Mulcahy R, Howard AN, Nolan JM, Griffiths HR. Phospholipid oxidation and carotenoid supplementation in Alzheimer’s disease patients Free Radic Biol Med. 2017 Jul;108:77-85.
9: Stamenkovic A, O’Hara KA, Nelson DC, Maddaford TG, Edel AL, Maddaford G, Dibrov E, Aghanoori M, Kirshenbaum LA, Fernyhough P, Aliani M, Pierce GN, Ravandi A. Oxidized phosphatidylcholines trigger ferroptosis in cardiomyocytes during ischemia-reperfusion injury Am J Physiol Heart Circ Physiol. 2021 Mar 1;320(3):H1170-H1184.
10: Seok JK, Hong EH, Yang G, Lee HE, Kim SE, Liu KH, Kang HC, Cho YY, Lee HS, Lee JY. Oxidized Phospholipids in Tumor Microenvironment Stimulate Tumor Metastasis via Regulation of Autophagy Cells. 2021 Mar 4;10(3):558.

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