Glycine-β-muricholic Acid

Product Description

Glycine-β-muricholic Acid
Catalog number: B2017558
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 1 mg
Molecular Weight or Concentration: 465.6
Supplied as: Powder
Applications: a molecular tool for various biochemical applications
Storage: -20°C
Keywords: Gly-MCA, GβMCA
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Hasan MN, Chen J, Wang H, Du Y, Clayton YD, Gu L, Li T. Glycine-β-Muricholic Acid Improves Liver Fibrosis and Gut Barrier Function by Reducing Bile Acid Pool Size and Hydrophobicity in Male Cyp2c70 Knockout Mice Cells. 2023 May 12;12(10):1371.
2: Jiang J, Ma Y, Liu Y, Lu D, Gao X, Krausz KW, Desai D, Amin SG, Patterson AD, Gonzalez FJ, Xie C. Glycine-β-muricholic acid antagonizes the intestinal farnesoid X receptor-ceramide axis and ameliorates NASH in mice Hepatol Commun. 2022 Dec;6(12):3363-3378.
3: Gonzalez FJ, Jiang C, Xie C, Patterson AD. Intestinal Farnesoid X Receptor Signaling Modulates Metabolic Disease Dig Dis. 2017;35(3):178-184.
4: Jiang C, Xie C, Lv Y, Li J, Krausz KW, Shi J, Brocker CN, Desai D, Amin SG, Bisson WH, Liu Y, Gavrilova O, Patterson AD, Gonzalez FJ. Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction Nat Commun. 2015 Dec 15;6:10166.
5: Liang LM, Zhou JJ, Xu F, Liu PH, Qin L, Liu L, Liu XD. Diabetes downregulates peptide transporter 1 in the rat jejunum: possible involvement of cholate-induced FXR activation Acta Pharmacol Sin. 2020 Nov;41(11):1465-1475.
6: Liu J, Lian G, Wang T, Ma Y, Zhou J, Jiang C, Yin Y. An HPLC-MS/MS method for quantitation of Gly-MCA in mouse plasma: Application to a pharmacokinetic study J Pharm Biomed Anal. 2017 Nov 30;146:53-58.
7: Cheng Y, Xiang X, Liu C, Cai T, Li T, Chen Y, Bai J, Shi H, Zheng T, Huang M, Fu W. Transcriptomic Analysis Reveals Lactobacillus reuteri Alleviating Alcohol-Induced Liver Injury in Mice by Enhancing the Farnesoid X Receptor Signaling Pathway J Agric Food Chem. 2022 Oct 5;70(39):12550-12564.
8: Hong S, Li S, Meng X, Li P, Wang X, Su M, Liu X, Liu L. Bile duct ligation differently regulates protein expressions of organic cation transporters in intestine, liver and kidney of rats through activation of farnesoid X receptor by cholate and bilirubin Acta Pharm Sin B. 2023 Jan;13(1):227-245.
9: Zhang L, Xie C, Nichols RG, Chan SH, Jiang C, Hao R, Smith PB, Cai J, Simons MN, Hatzakis E, Maranas CD, Gonzalez FJ, Patterson AD. Farnesoid X Receptor Signaling Shapes the Gut Microbiota and Controls Hepatic Lipid Metabolism mSystems. 2016 Oct 11;1(5):e00070-16.
10: Gonzalez FJ, Jiang C, Patterson AD. An Intestinal Microbiota-Farnesoid X Receptor Axis Modulates Metabolic Disease Gastroenterology. 2016 Nov;151(5):845-859.

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