Chronic prolonged hyponatremia and risk of hip fracture in elderly patients with chronic kidney disease.

A new interesting article has been published in Bone. 2019 Jul 27;127:556-562. doi: 10.1016/j.bone.2019.07.029. and titled:

Chronic prolonged hyponatremia and risk of hip fracture in elderly patients with chronic kidney disease.

Authors of this article are:

Nigwekar SU, Negri AL, Bajpai D, Allegretti A, Kalim S, Seethapathy H, Bhan I, Murthy K, Ayus JC.

A summary of the article is shown below:

BACKGROUND: Chronic prolonged hyponatremia (CPH) is a risk factor for hip fracture in the general population. Whether CPH increases hip fracture risk in chronic kidney disease (CKD) patients is unknown.METHODS: Case-control study in patients over 60 years of age with stage 3 or greater CKD. Patients who had a hip fracture were referred to as cases (n = 1236) and controls had no hip fracture (n = 4515). Patients were classified as having CPH if serum sodium was <135 mEq/L on at least two occasions separated by a minimum of 90 days prior to the diagnosis of hip fracture (cases) or at any time during the study period (controls). Conditional logistic regression models were used to test the association between CPH and hip fracture. Analyses were conducted for patients with and without osteoporosis and falls and for patients with age >70 years versus ≤70 years.RESULTS: CPH was present in 21% of cases and 10% of controls (p < 0.001; sodium level: 131-134 mEq/L). In univariate logistic regression analysis, CPH was associated with higher odds of hip fracture (odds ratio [OR] 2.44, (95% [CI] 2.07-2.89). In a multivariate model adjusted for comorbidities, medications and laboratory parameters CPH association with higher odds of Hip fracture was attenuated but remained significant (OR 1.36, 95% CI 1.04-1.78). The association between CPH and risk of hip fracture was consistent in patients with or without osteoporosis and falls and across the age strata.CONCLUSION: Chronic prolonged hyponatremia is a risk factor for hip fracture in CKD patients older than 60 years of age.Copyright © 2019. Published by Elsevier Inc.
Check out the article’s website on Pubmed for more information:



This article is a good source of information and a good way to become familiar with topics such as: Chronic hyponatremia;Chronic kidney disease;Falls;Hip fracture;Osteoporosis.

Molecular Depot

Your specialty peptide, proteins, antibodies and chemical compounds store.