Adipogenesis associated Mth938 domain containing (AAMDC) protein expression is regulated by alternative polyadenylation and microRNAs.

A new interesting article has been published in FEBS Lett. 2019 May 22. doi: 10.1002/1873-3468.13449. and titled:

Adipogenesis associated Mth938 domain containing (AAMDC) protein expression is regulated by alternative polyadenylation and microRNAs.

Authors of this article are:

Xiao R, Li C, Wang C, Cao Y, Zhang L, Guo Y, Xin Y, Zhang H, Zhou G.

A summary of the article is shown below:

The post-transcriptional events regulating expression of the adipogenesis associated Mth938 domain containing (AAMDC) protein are poorly understood. Here, we find that AAMDC expresses three isoforms due to alternative polyadenylation (APA) and alternative splicing (AS). Luciferase assay revealed that expression of the two isoforms with short and long 3’untranslated regions (3’UTRs) is differentially controlled. Further analyses showed that the short isoform displays higher translation efficiency and that miR-2428/664a reduces expression of the long isoform, indicating that APA-mediated shortening of the AAMDC 3’UTR renders the short isoform insusceptible to miRNA-mediated suppression due to loss of the binding sites for miR-2428/664a. Finally, we demonstrate that the short AAMDC isoform promotes bovine preadipocyte differentiation. Collectively, our findings indicate that AAMDC is post-transcriptionally regulated through APA and microRNAs (miRNAs). This article is protected by copyright. All rights reserved.This article is protected by copyright. All rights reserved.

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This article is a good source of information and a good way to become familiar with topics such as: AAMDC ; alternative polyadenylation; differentiation; epigenetics; microRNAs.