A diagnostic test accuracy meta-analysis of maternal serum ischemia-modified albumin for detection of preeclampsia.

A new interesting article has been published in J Matern Fetal Neonatal Med. 2019 Jul;32(13):2173-2181. doi: 10.1080/14767058.2018.1427724. Epub 2018 Jan 24. Meta-Analysis; Systematic Review and titled:

A diagnostic test accuracy meta-analysis of maternal serum ischemia-modified albumin for detection of preeclampsia.

Authors of this article are:

Seshadri Reddy V, Munikumar M, Duggina P, Varma N.

A summary of the article is shown below:

BACKGROUND/AIMS: Ischemia-modified albumin (IMA) has been widely accepted as a serological biomarker. IMA has been proposed as a simple and novel marker of oxidative stress in preeclampsia (PE). This systematic review and diagnostic test accuracy meta-analysis aims to evaluate the diagnostic accuracy of this novel serological biomarker, IMA to detect PE.METHODS: A systematic search of major databases was performed to identify all published diagnostic accuracy studies on IMA. Risk of bias and applicability concerns were assessed for included studies. Summary estimates; the pooled sensitivity, specificity, and the diagnostic odds ratio (DOR) of IMA for the diagnosis of PE were computed using random-effects models. The overall test performance was summarized using summary receiver operating characteristic (SROC) curve analysis.RESULTS: Six articles were included in this meta-analysis. The overall estimates of IMA in detecting PE were pooled sensitivity; 0.80 (95%CI 0.73-0.86), pooled specificity; 0.76 (95%CI 0.70-0.81), DOR; 14.32 (95%CI 5.06-40.57), and area under curve (AUC); 0.860. There was no between-study heterogeneity due to threshold effect.CONCLUSIONS: This meta-analysis showed IMA could be useful as a biomarker for PE with good accuracy (AUC = 0.860). However, further research is needed for re-evaluation and clinical validation of fairly promising results of this meta-analysis.

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This article is a good source of information and a good way to become familiar with topics such as: Area Under Curve;Biomarkers;Diagnostic Tests, Routine;Female;Humans;Oxidative Stress;Pre-Eclampsia;Pregnancy;Reproducibility of Results;Sensitivity and Specificity;Serum Albumin, Human.