RNA control in pain: Blame it on the messenger.
Authors of this article are:
de la Peña JBI, Song JJ, Campbell ZT.
A summary of the article is shown below:
mRNA function is meticulously controlled. We provide an overview of the integral role that posttranscriptional controls play in the perception of painful stimuli by sensory neurons. These specialized cells, termed nociceptors, precisely regulate mRNA polarity, translation, and stability. A growing body of evidence has revealed that targeted disruption of mRNAs and RNA-binding proteins robustly diminishes pain-associated behaviors. We propose that the use of multiple independent regulatory paradigms facilitates robust temporal and spatial precision of protein expression in response to a range of pain-promoting stimuli. This article is categorized under: RNA in Disease and Development > RNA in Disease Translation > Translation Regulation RNA Turnover and Surveillance > Regulation of RNA Stability.© 2019 Wiley Periodicals, Inc.
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This article is a good source of information and a good way to become familiar with topics such as: nociceptor; pain; plasticity.