Qigesan reduces the motility of esophageal cancer cells via inhibiting Gas6/Axl and NF-κB expression.

A new interesting article has been published in Biosci Rep. 2019 May 20. pii: BSR20190850. doi: 10.1042/BSR20190850. and titled:

Qigesan reduces the motility of esophageal cancer cells via inhibiting Gas6/Axl and NF-κB expression.

Authors of this article are:

Kong L, Wu Z, Zhao Y, Lu X, Shi H, Liu S, Li J.

A summary of the article is shown below:

This study is mainly to explore the mechanism that how QGS affect the movement capacity of esophageal cancer cell.QGS incubates ECA109 and TE1 cell lines, and detecting the motility of tumor Cells by different experiments.Growth arrest-specific 6 (Gas6) and Anexelekto(Axl)was co-localized,and then detecting Gas6,Axl signaling pathway and protein expression after QGS intervention.Similarly, Observing the signal localization and protein expression of P-Phosphoinositide3-kinases (PI3K),P-AKT Protein kinase B (AKT),P-Nuclear factor-kappa B(NF-κB),Matrix Metalloproteinase-2(MMP2) and Matrix Metalloproteinase-9(MMP9). The results showed that the concentration of QGS was less than 200 ug/ml, and the cultured cells did not exceed 24 h, that no obvious cytotoxicity was observed.QGS significantly inhibited the mobility of ECA109 and TE1 cell lines in the concentration-dependent manner.In addition, QGS can regulate the Gas6/Axl pathway, inhibit the formation and localization of the Gas6/Axl complex,and reduce the protein activation of PI3K/AKT,NF-κB,MMP2 and MMP9.Experimental innovation shows that QGS can significantly slow down the mobility of EC cells by regulating the Gas6/Axl complex and downstream signaling pathways,and provides a theoretical basis for the pharmacological effects of QGS in the therapy of EC.©2019 The Author(s).

Check out the article’s website on Pubmed for more information:

This article is a good source of information and a good way to become familiar with topics such as: ESCC; Gas6/Axl; Invasion; Migration; Qigesan.

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