STAT1 drives M1 microglia activation and neuroinflammation under hypoxia.

A new interesting article has been published in Arch Biochem Biophys. 2019 May 20;669:22-30. doi: 10.1016/j.abb.2019.05.011. and titled:

STAT1 drives M1 microglia activation and neuroinflammation under hypoxia.

Authors of this article are:

Butturini E, Boriero D, Carcereri de Prati A, Mariotto S.

A summary of the article is shown below:

Microglia are resident immune cells that act as the first active defence in the central nervous system. These cells constantly monitor the tissue microenvironment and rapidly react in response to hypoxia, infection and injuries. Hypoxia in the brain has been detected in several neurodegenerative disorders such as Alzheimer’s disease, amyotrophic lateral sclerosis, Parkinson’s disease and Huntington’s disease. Hypoxic conditions activate microglia cells towards M1 phenotype resulting in oxidative stress and the release of pro-inflammatory cytokines. Recently, we have demonstrated that oxidative stress induces S-glutathionylation of the STAT1 and hyper-activates its signaling in microglia BV2 cells pointing out the importance of this transcription factor in neuroinflammation. In this paper we analyse the cellular mechanisms that drive M1 microglia activation in BV2 cells in response to hypoxia correlating it to STAT1 activation. The analysis of the molecular mechanism of STAT1 signaling reveals that hypoxia generates oxidative stress and induces both phosphorylation and S-glutathionylation of STAT1 that are responsible of its aberrant activation. The silencing of STAT1 protein expression counteracts hypoxia-M1 microglia phenotype suggesting the strong link between hypoxia-STAT1 and STAT1-microglia activation.Copyright © 2019. Published by Elsevier Inc.

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This article is a good source of information and a good way to become familiar with topics such as: M1 microglia activation; Neuroinflammation; Oxidative stress; S-glutathionylation; STAT1.