Adalimumab improves cognitive impairment, exerts neuroprotective effects and attenuates neuroinflammation in an Aβ1-40-injected mouse model of Alzh…

A new interesting article has been published in Cytotherapy. 2019 May 7. pii: S1465-3249(19)30458-X. doi: 10.1016/j.jcyt.2019.04.054. and titled:

Adalimumab improves cognitive impairment, exerts neuroprotective effects and attenuates neuroinflammation in an Aβ1-40-injected mouse model of Alzh…

Authors of this article are:

Park J, Lee SY, Shon J, Kim K, Lee HJ, Kim KA, Lee BY, Oh SH, Kim NK, Kim OJ.

A summary of the article is shown below:

The pathogenesis of Alzheimer’s disease (AD) is associated with an increased inflammatory response via activated microglia and astrocytes. In the present study, we investigated whether treatment with the anti-tumor necrosis factor alpha (TNF-α) monoclonal antibody adalimumab can improve cognitive function and reduce AD pathology in Aβ1-40-injected animal models of AD, as well as the mechanisms underlying the effects of treatment. Aβ1-40-injected mice treated with adalimumab exhibited significant improvements in memory relative to mice injected with Aβ1-40 alone, as well as decreases in beta secretase-1 (BACE1) protein expression and Aβ1-40 plaques. In addition, adalimumab treatment significantly attenuated neuronal damage and neuroinflammation in Aβ1-40-injected mice. Aβ1-40-induced decreases in brain-derived neurotrophic factor (BDNF) expression were also attenuated by treatment with adalimumab. Our experiments further verified that the effects of adalimumab are mediated by nuclear factor kappa B (NF-κB) p65 signalling. Serine 536 residues of NF-κB p65, which is phosphorylated by TNF-α, increased along with the degradation of inhibitor of κB (IκB) in the hippocampus of Aβ-injected mice, although these effects were again attenuated by adalimumab. Furthermore, Aβ1-40-induced increases in TNF-α and interleukin (IL)-6 expression were decreased by treatment with adalimumab. Our results indicate that adalimumab may be clinically useful in human patients with AD.Copyright © 2019 International Society for Cell and Gene Therapy. Published by Elsevier Inc. All rights reserved.

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This article is a good source of information and a good way to become familiar with topics such as: Alzheimer’s disease; adalimumab; neuroinflammation; neuroprotection.

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