Ubiquitin Aldehyde human

Description

Ubiquitin Aldehyde human
Catalog number: B2013643
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 50 μg
Molecular Weight or Concentration: 8.5 kDa
Supplied as: Solution
Applications: molecular tool for various biochemical applications
Storage: -20°C
Keywords: Ubiquitin Aldehyde human
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Wiener R, Zhang X, Wang T, Wolberger C. The mechanism of OTUB1-mediated inhibition of ubiquitination Nature. 2012 Feb 22;483(7391):618-22.
2: Liao Y, Yang M, Wang K, Wang Y, Zhong B, Jiang N. Deubiquitinating enzyme OTUB1 in immunity and cancer: Good player or bad actor? Cancer Lett. 2022 Feb 1;526:248-258.
3: Chen S, Bu D, Zhu J, Yue T, Guo S, Wang X, Pan Y, Liu Y, Wang P. Endogenous hydrogen sulfide regulates xCT stability through persulfidation of OTUB1 at cysteine 91 in colon cancer cells Neoplasia. 2021 May;23(5):461-472.
4: Shaeffer JR, Cohen RE. Differential effects of ubiquitin aldehyde on ubiquitin and ATP-dependent protein degradation Biochemistry. 1996 Aug 20;35(33):10886-93.
5: Zhu Q, Fu Y, Li L, Liu CH, Zhang L. The functions and regulation of Otubains in protein homeostasis and diseases Ageing Res Rev. 2021 May;67:101303.
6: Ye D, Wang S, Wang X, Lin Y, Huang Y, Chi P. Overexpression of OTU domain-containing ubiquitin aldehyde-binding protein 1 exacerbates colorectal cancer malignancy by inhibiting protein degradation of β-Catenin via Ubiquitin-proteasome pathway Bioengineered. 2022 Apr;13(4):9106-9116.
7: Baek KH. Cytokine-regulated protein degradation by the ubiquitination system Curr Protein Pept Sci. 2006 Apr;7(2):171-7.
8: Pei HZ, Huang B, Chang HW, Baek SH. Ovarian tumor domain-containing ubiquitin aldehyde binding protein 1 inhibits inflammation by regulating Nur77 stability Cell Signal. 2019 Jul;59:85-95.
9: Li J, Zhang N, Li M, Hong T, Meng W, Ouyang T. The Emerging Role of OTUB2 in Diseases: From Cell Signaling Pathway to Physiological Function Front Cell Dev Biol. 2022 Mar 2;10:820781.
10: Sivakumar D, Kumar V, Naumann M, Stein M. Activation and selectivity of OTUB-1 and OTUB-2 deubiquitinylases J Biol Chem. 2020 May 15;295(20):6972-6982.

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