MMP-2 Substrate Fluorogenic

Description

MMP-2 Substrate Fluorogenic
Catalog number: B2013672
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 1 mg
Molecular Weight or Concentration: 1093.2 g/mol
Supplied as: Powder
Applications: molecular tool for various biochemical applications
Storage: -20°C
Keywords: MMP-2 Substrate, Fluorogenic
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Akers WJ, Xu B, Lee H, Sudlow GP, Fields GB, Achilefu S, Edwards WB. Detection of MMP-2 and MMP-9 activity in vivo with a triple-helical peptide optical probe Bioconjug Chem. 2012 Mar 21;23(3):656-63.
2: Lamort AS, Gravier R, Laffitte A, Juliano L, Zani ML, Moreau T. New insights into the substrate specificity of macrophage elastase MMP-12 Biol Chem. 2016 May;397(5):469-84.
3: Hwang Q, Cheifetz S, Overall CM, McCulloch CA, Sodek J. Bone sialoprotein does not interact with pro-gelatinase A (MMP-2) or mediate MMP-2 activation BMC Cancer. 2009 Apr 22;9:121.
4: Kirchhain A, Zubrien A, Kairys V, Vivaldi F, Bonini A, Biagini D, Santalucia D, Matulis D, Di Francesco F. Biphenyl substituted lysine derivatives as recognition elements for the matrix metalloproteinases MMP-2 and MMP-9 Bioorg Chem. 2021 Oct;115:105155.
5: Bourguet E, Brazhnik K, Sukhanova A, Moroy G, Brassart-Pasco S, Martin AP, Villena I, Bellon G, Sapi J, Nabiev I. Design, Synthesis, and Use of MMP-2 Inhibitor-Conjugated Quantum Dots in Functional Biochemical Assays Bioconjug Chem. 2016 Apr 20;27(4):1067-81.
6: Jacob-Ferreira AL, Kondo MY, Baral PK, James MN, Holt A, Fan X, Schulz R. Phosphorylation status of 72 kDa MMP-2 determines its structure and activity in response to peroxynitrite PLoS One. 2013 Aug 27;8(8):e71794.
7: Nagase H, Fields CG, Fields GB. Design and characterization of a fluorogenic substrate selectively hydrolyzed by stromelysin 1 (matrix metalloproteinase-3) J Biol Chem. 1994 Aug 19;269(33):20952-7.
8: Carrilho MR, Scaffa P, Oliveira V, Tj_derhane L, Tersariol IL, Pashley DH, Tay F, Nascimento FD. Insights into cathepsin-B activity in mature dentin matrix Arch Oral Biol. 2020 Sep;117:104830.
9: Lauer-Fields JL, Fields GB. Triple-helical peptide analysis of collagenolytic protease activity Biol Chem. 2002 Jul-Aug;383(7-8):1095-105.
10: Samtani S, Amaral J, Campos MM, Fariss RN, Becerra SP. Doxycycline-mediated inhibition of choroidal neovascularization Invest Ophthalmol Vis Sci. 2009 Nov;50(11):5098-106.

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