LKB1(STK11) Protein

Description

LKB1(STK11) Protein
Catalog number: B2014674
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 25 μg
Molecular Weight or Concentration: 85 kDa
Supplied as: Solution
Applications: molecular tool for various biochemical applications
Storage: −20°C
Keywords: LKB1(STK11) Protein
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Marinaccio C, Suraneni P, Celik H, Volk A, Wen QJ, Ling T, Bulic M, Lasho T, Koche RP, Famulare CA, Farnoud N, Stein B, Schieber M, Gurbuxani S, Root DE, Younger ST, Hoffman R, Gangat N, Ntziachristos P, Chandel NS, Levine RL, Rampal RK, Challen GA, Tefferi A, Crispino JD. LKB1/STK11 Is a Tumor Suppressor in the Progression of Myeloproliferative Neoplasms Cancer Discov. 2021 Jun;11(6):1398-1410.
2: Hollstein PE, Eichner LJ, Brun SN, Kamireddy A, Svensson RU, Vera LI, Ross DS, Rymoff TJ, Hutchins A, Galvez HM, Williams AE, Shokhirev MN, Screaton RA, Berdeaux R, Shaw RJ. The AMPK-Related Kinases SIK1 and SIK3 Mediate Key Tumor-Suppressive Effects of LKB1 in NSCLC Cancer Discov. 2019 Nov;9(11):1606-1627.
3: Menko FH. LKB1/ STK11, Peutz-Jeghers syndrome and cancer. Introduction Fam Cancer. 2011 Sep;10(3):413-4.
4: Rho SB, Byun HJ, Kim BR, Lee CH. LKB1/STK11 Tumor Suppressor Reduces Angiogenesis by Directly Interacting with VEGFR2 in Tumorigenesis Biomol Ther (Seoul). 2023 Jul 1;31(4):456-465.
5: Mitchell KG, Parra ER, Zhang J, Nelson DB, Corsini EM, Villalobos P, Moran CA, Skoulidis F, Wistuba II, Fujimoto J, Roth JA, Antonoff MB; MD Anderson Lung Cancer Immune Microenvironment Working Group. LKB1/STK11 Expression in Lung Adenocarcinoma and Associations With Patterns of Recurrence Ann Thorac Surg. 2020 Oct;110(4):1131-1138.
6: Sapkota GP, Kieloch A, Lizcano JM, Lain S, Arthur JS, Williams MR, Morrice N, Deak M, Alessi DR. Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowth J Biol Chem. 2001 Jun 1;276(22):19469-82.
7: Bosman FT. The hamartoma-adenoma-carcinoma sequence J Pathol. 1999 May;188(1):1-2.
8: Launonen V. Mutations in the human LKB1/STK11 gene Hum Mutat. 2005 Oct;26(4):291-7.
9: Facchinetti F, Bluthgen MV, Tergemina-Clain G, Faivre L, Pignon JP, Planchard D, Remon J, Soria JC, Lacroix L, Besse B. LKB1/STK11 mutations in non-small cell lung cancer patients: Descriptive analysis and prognostic value Lung Cancer. 2017 Oct;112:62-68.
10: Fumet JD, Limagne E, Thibaudin M, Truntzer C, Bertaut A, Rederstorff E, Ghiringhelli F. Precision medicine phase II study evaluating the efficacy of a double immunotherapy by durvalumab and tremelimumab combined with olaparib in patients with solid cancers and carriers of homologous recombination repair genes mutation in response or stable after olaparib treatment BMC Cancer. 2020 Aug 10;20(1):748.

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