Kininogen (High Molecular Weight)

Description

Kininogen (High Molecular Weight)
Catalog number: B2013435
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 1 mg
Molecular Weight or Concentration: 120 kDa
Supplied as: Solution
Applications: molecular tool for various biochemical applications
Storage: -20°C
Keywords: Kininogen
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Ponczek MB. High Molecular Weight Kininogen: A Review of the Structural Literature Int J Mol Sci. 2021 Dec 13;22(24):13370.
2: Droll SH, Hsu YS, Drake SK, Kim A, Wang W, Calvo KR, Cao Z, Hu TY, Zhao Z. Differential processing of high-molecular-weight kininogen during normal pregnancy Rapid Commun Mass Spectrom. 2020 Apr;34 Suppl 1(Suppl 1):e8552.
3: Hofman ZLM, De Maat S, Maas C. High-molecular-weight kininogen: breaking bad in lethal endotoxemia J Thromb Haemost. 2018 Feb;16(2):193-195.
4: Zamolodchikov D, Duffield M, Macdonald LE, Alessandri-Haber N. Accumulation of high molecular weight kininogen_ in the brains of Alzheimer’s disease patients may affect microglial function by altering phagocytosis and lysosomal cathepsin activity Alzheimers Dement. 2022 Oct;18(10):1919-1929.
5: Sparkenbaugh EM, Kasztan M, Henderson MW, Ellsworth P, Davis PR, Wilson KJ, Reeves B, Key NS, Strickland S, McCrae K, Pollock DM, Pawlinski R. High molecular weight kininogen contributes to early mortality and kidney dysfunction in a mouse model of sickle cell disease J Thromb Haemost. 2020 Sep;18(9):2329-2340.
6: Guo YL, Colman RW. Two faces of high-molecular-weight kininogen_ (HK) in angiogenesis: bradykinin turns it on and cleaved HK (HKa) turns it off J Thromb Haemost. 2005 Apr;3(4):670-6.
7: Turk B, Stoka V, Turk V, Johansson G, Cazzulo JJ, Björk I. High-molecular-weight kininogen_ binds two molecules of cysteine proteinases with different rate constants FEBS Lett. 1996 Aug 5;391(1-2):109-12.
8: Isordia-Salas I, Pixley RA, Sáinz IM, Martínez-Murillo C, Colman RW. The role of plasma high molecular weight kininogen_ in experimental intestinal and systemic inflammation Arch Med Res. 2004 Sep-Oct;35(5):369-77.
9: McCrae KR, Doñate F, Merkulov S, Sun D, Qi X, Shaw DE. Inhibition of angiogenesis by cleaved high molecular weight kininogen_ (HKa) and HKa domain 5 Curr Cancer Drug Targets. 2005 Nov;5(7):519-28.
10: Ishimaru F, Hayashi H. [High molecular weight kininogen deficiency] Ryoikibetsu Shokogun Shirizu. 1998;(21 Pt 2):434-6.

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