Human TATA Box Binding Protein (TBP)


Catalog Number: B2014217 (5 μg)
Human TATA Box Binding Protein (TBP) is a high quality recombinant Human TATA Box Binding Protein (TBP) expressed in E. coli. This product has been used as molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request.

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Human TATA Box Binding Protein (TBP)
Catalog number: B2014217
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 5 μg
Molecular Weight or Concentration: 64.4 kDa
Supplied as: Solution
Applications: molecular tool for various biochemical applications
Storage: −20°C
Keywords: GTF2D, GTF2D1, HDL4, MGC117320, MGC126054, MGC126055, SCA17, TFIID
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

1: Tjitro R, Campbell LA, Basova L, Johnson J, Najera JA, Lindsey A, Marcondes MCG. Modeling the Function of TATA Box Binding Protein in Transcriptional Changes Induced by HIV-1 Tat in Innate Immune Cells and the Effect of Methamphetamine Exposure Front Immunol. 2019 Feb 4;9:3110.
2: Hardivill S, Banerjee PS, Selen Alpergin ES, Smith DM, Han G, Ma J, Talbot CC Jr, Hu P, Wolfgang MJ, Hart GW. TATA-Box Binding Protein O-GlcNAcylation at T114 Regulates Formation of the B-TFIID Complex and Is Critical for Metabolic Gene Regulation Mol Cell. 2020 Mar 5;77(5):1143-1152.e7.
3: Berciano J. Commentary Mov Disord. 2014 Jan;29(1):38-9.
4: Magri S, Nanetti L, Gellera C, Sarto E, Rizzo E, Mongelli A, Ricci B, Fancellu R, Sambati L, Cortelli P, Brusco A, Bruzzone MG, Mariotti C, Di Bella D, Taroni F. Digenic inheritance of STUB1 variants and TBP polyglutamine expansions explains the incomplete penetrance of SCA17 and SCA48 Genet Med. 2022 Jan;24(1):29-40.
5: Huang S, Ling JJ, Yang S, Li XJ, Li S. Neuronal expression of TATA box-binding protein containing expanded polyglutamine in knock-in mice reduces chaperone protein response by impairing the function of nuclear factor-Y transcription factor Brain. 2011 Jul;134(Pt 7):1943-58.
6: Arkova O, Kuznetsov N, Fedorova O, Savinkova L. A real-time study of the interaction of TBP with a TATA box-containing duplex identical to an ancestral or minor allele of human gene LEP or TPI J Biomol Struct Dyn. 2017 Nov;35(14):3070-3081.
7: Zabierowski SE, Deluca NA. Stabilized binding of TBP to the TATA box of herpes simplex virus type 1 early (tk) and late (gC) promoters by TFIIA and ICP4 J Virol. 2008 Apr;82(7):3546-54.
8: Nakamori M, Panigrahi GB, Lanni S, Gall-Duncan T, Hayakawa H, Tanaka H, Luo J, Otabe T, Li J, Sakata A, Caron MC, Joshi N, Prasolava T, Chiang K, Masson JY, Wold MS, Wang X, Lee MYWT, Huddleston J, Munson KM, Davidson S, Layeghifard M, Edward LM, Gallon R, Santibanez-Koref M, Murata A, Takahashi MP, Eichler EE, Shlien A, Nakatani K, Mochizuki H, Pearson CE. A slipped-CAG DNA-binding small molecule induces trinucleotide-repeat contractions in vivo Nat Genet. 2020 Feb;52(2):146-159.
9: Xu Q, Li XH, Wang JL, Jiang H, Zhang S, Lei LF, Shen L, Xia K, Pan Q, Long ZG, Tang BS. Mutation analysis of the TATA box-binding protein (TBP) gene in Chinese Han patients with spinocerebellar ataxia J Clin Neurosci. 2009 Oct;16(10):1374-5.
10: Delgadillo RF, Whittington JE, Parkhurst LK, Parkhurst LJ. The TATA-binding protein core domain in solution variably bends TATA sequences via a three-step binding mechanism Biochemistry. 2009 Mar 3;48(8):1801-9.

Products Related to Human TATA Box Binding Protein (TBP) can be found at Proteins

Additional information

Weight 48 oz
Dimensions 8 × 8 × 8 in

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