Human MEK2 Protein Inactive

Description

Human MEK2 Protein Inactive
Catalog number: B2014001
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 50 μg
Molecular Weight or Concentration: 46 kDa
Supplied as: N/A
Applications: molecular tool for various biochemical applications
Storage: −20°C
Keywords: MEK2 Protein
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Kan G, Wang Z, Sheng C, Chen G, Yao C, Mao Y, Chen S. Dual Inhibition of DKC1 and MEK1/2 Synergistically Restrains the Growth of Colorectal Cancer Cells Adv Sci (Weinh). 2021 Mar 15;8(10):2004344.
2: Park E, Rawson S, Li K, Kim BW, Ficarro SB, Pino GG, Sharif H, Marto JA, Jeon H, Eck MJ. Architecture of autoinhibited and active BRAF-MEK1-14-3-3 complexes Nature. 2019 Nov;575(7783):545-550.
3: Wan PT, Garnett MJ, Roe SM, Lee S, Niculescu-Duvaz D, Good VM, Jones CM, Marshall CJ, Springer CJ, Barford D, Marais R; Cancer Genome Project. Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF Cell. 2004 Mar 19;116(6):855-67.
4: Reiterer V, Pawowski K, Farhan H. STYX: a versatile pseudophosphatase Biochem Soc Trans. 2017 Apr 15;45(2):449-456.
5: Hari SB, Merritt EA, Maly DJ. Sequence determinants of a specific inactive protein kinase conformation Chem Biol. 2013 Jun 20;20(6):806-15.
6: Brott BK, Alessandrini A, Largaespada DA, Copeland NG, Jenkins NA, Crews CM, Erikson RL. MEK2 is a kinase related to MEK1 and is differentially expressed in murine tissues Cell Growth Differ. 1993 Nov;4(11):921-9.
7: Hsiao KM, Chou SY, Shih SJ, Ferrell JE Jr. Evidence that inactive p42 mitogen-activated protein kinase and inactive Rsk exist as a heterodimer in vivo Proc Natl Acad Sci U S A. 1994 Jun 7;91(12):5480-4.
8: Pouyssgur J, Volmat V, Lenormand P. Fidelity and spatio-temporal control in MAP kinase (ERKs) signalling Biochem Pharmacol. 2002 Sep;64(5-6):755-63.
9: Wang W, Krosky D, Ahn K. Discovery of Inactive Conformation-Selective Kinase Inhibitors by Utilizing Cascade Assays Biochemistry. 2017 Aug 29;56(34):4449-4456.
10: Aoto PC, Stanfield RL, Wilson IA, Dyson HJ, Wright PE. A Dynamic Switch in Inactive p38_ Leads to an Excited State on the Pathway to an Active Kinase Biochemistry. 2019 Dec 24;58(51):5160-5172.

Products Related to Human MEK2 Protein Inactive can be found at Proteins