Human CIAO1 Protein

Description

Human CIAO1 Protein
Catalog number: B2011954
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 100 µg
Molecular Weight or Concentration: 1 mg/mL
Supplied as: Solution
Applications: fluorescent dye commonly used as a tracer agent
Storage: -20 °C
Keywords: Probable cytosolic iron-sulfur protein assembly protein CIAO1 protein, CIA1 protein, WDR39 protein, CIAO1, CIAO 1, CIAO-1, CIAO 1 protein, CIAO-1 protein
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Nan H, Kim YJ, Tsuchiya M, Fukao T, Hara N, Hagihara A, Nishioka K, Hattori N, Hara N, Ikeuchi T, Ohtsuka T, Takiyama Y. A Novel Heterozygous Missense Variant in the CIAO1 Gene in a Family with Alzheimer’s Disease: The Val67Ile Variant Promotes the Interaction of CIAO1 and Amyloid-β Protein Precursor J Alzheimers Dis. 2021;84(2):599-605.
2: Maione V, Cantini F, Severi M, Banci L. Investigating the role of the human CIA2A-CIAO1 complex in the maturation of aconitase Biochim Biophys Acta Gen Subj. 2018 Sep;1862(9):1980-1987.
3: Maione V, Grifagni D, Torricella F, Cantini F, Banci L. CIAO3 protein forms a stable ternary complex with two key players of the human cytosolic iron-sulfur cluster assembly machinery J Biol Inorg Chem. 2020 May;25(3):501-508.
4: Kassube SA, Thomä NH. Structural insights into Fe-S protein biogenesis by the CIA targeting complex Nat Struct Mol Biol. 2020 Aug;27(8):735-742.
5: Moiseeva TN, Gamper AM, Hood BL, Conrads TP, Bakkenist CJ. Human DNA polymerase ε is phosphorylated at serine-1940 after DNA damage and interacts with the iron-sulfur complex chaperones CIAO1 and MMS19 DNA Repair (Amst). 2016 Jul;43:9-17.
6: Seki M, Takeda Y, Iwai K, Tanaka K. IOP1 protein is an external component of the human cytosolic iron-sulfur cluster assembly (CIA) machinery and functions in the MMS19 protein-dependent CIA pathway J Biol Chem. 2013 Jun 7;288(23):16680-16689.
7: Srinivasan V, Netz DJ, Webert H, Mascarenhas J, Pierik AJ, Michel H, Lill R. Structure of the yeast WD40 domain protein Cia1, a component acting late in iron-sulfur protein biogenesis Structure. 2007 Oct;15(10):1246-57.
8: Maio N, Rouault TA. Outlining the Complex Pathway of Mammalian Fe-S Cluster Biogenesis Trends Biochem Sci. 2020 May;45(5):411-426.
9: Stehling O, Mascarenhas J, Vashisht AA, Sheftel AD, Niggemeyer B, Rösser R, Pierik AJ, Wohlschlegel JA, Lill R. Human CIA2A-FAM96A and CIA2B-FAM96B integrate iron homeostasis and maturation of different subsets of cytosolic-nuclear iron-sulfur proteins Cell Metab. 2013 Aug 6;18(2):187-98.
10: Upadhyay AS, Stehling O, Panayiotou C, Rösser R, Lill R, Överby AK. Cellular requirements for iron-sulfur cluster insertion into the antiviral radical SAM protein viperin J Biol Chem. 2017 Aug 18;292(33):13879-13889.

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