DACM (N-(7-Dimethylamino-4-methylcoumarin-3-yl)maleimide)


Catalog Number: B2011420 (5 mg)
DACM (N-(7-Dimethylamino-4-methylcoumarin-3-yl)maleimide) is a high quality blue fluorescent thiol-reactive reagent for probing the structure of proteins. This product has been used as molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request.

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SKU: B2011420 Categories: ,


DACM (N-(7-Dimethylamino-4-methylcoumarin-3-yl)maleimide)
Catalog number: B2011420
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 5 mg
Molecular Weight or Concentration: 298.3 g/mol
Supplied as: Lyophilized
Applications: molecular tool for various biochemical applications
Storage: -20 °C
Keywords: N-(7-Dimethylamino-4-methylcoumarin-3-yl)maleimide
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

1: Namihisa T, Saifuku K, Ishii H, Watanabe S, Sekine T. N-(7-dimethylamino-4-methylcoumarinyl)-maleimide (DACM): an alternative label for fluorescence tracing J Immunol Methods. 1983;56(1):125-34.
2: Caporusso J, Abdo R, Karr J, Smith M, Anaim A. Clinical experience using a dehydrated amnion/chorion membrane construct for the management of wounds Wounds. 2019 Apr;31(4 Suppl):S19-S27.
3: McQuilling JP, Kimmerling KA, Staples MC, Mowry KC. Evaluation of two distinct placental-derived membranes and their effect on tenocyte responses in vitro J Tissue Eng Regen Med. 2019 Aug;13(8):1316-1330.
4: Taneda A, Ogawa H, Hashimoto K. The histochemical demonstration of protein-bound sulfhydryl groups and disulfide bonds in human hair by a new staining method (DACM staining) J Invest Dermatol. 1980 Oct;75(4):365-9.
5: Kanamori M, Shimizu M. The -SH and SS positive components in dermal connective tissues: a study by N-(7-dimethylamino-4-methyl-3-coumarinyl) maleimide (DACM) stain Arch Dermatol Res. 1987;279(6):406-11.
6: Seeley JP, Cotlet M, Eagleton AM, Higashiya S, Welch JT. Resonance Energy Transfer in a Genetically Engineered Polypeptide Results in Unanticipated Fluorescence Intensity Chemistry. 2019 Jan 18;25(4):961-965.
7: Pravatà G, Noto G, Aricò M. Increased SS bonds in chronic solar elastosis: a study with N-(7-dimethylamino-4-methyl-3-coumarinyl) maleimide (DACM) stain J Dermatol Sci. 1994 Feb;7(1):14-23.
8: Qiu L, Wang Y, Wu H, Sun Y, Cui H, Zhao W, Yuan L, Zhan C. Three-dimensional resolution-enhancement divided aperture correlation-differential confocal microscopy with nanometer axial focusing capability Opt Express. 2018 Feb 5;26(3):2314-2324.
9: McQuilling JP, Burnette M, Kimmerling KA, Kammer M, Mowry KC. A mechanistic evaluation of the angiogenic properties of a dehydrated amnion chorion membrane in vitro and in vivo Wound Repair Regen. 2019 Nov;27(6):609-621.
10: Small KL, Henthorn NT, Angal-Kalinin D, Chadwick AL, Santina E, Aitkenhead A, Kirkby KJ, Smith RJ, Surman M, Jones J, Farabolini W, Corsini R, Gamba D, Gilardi A, Merchant MJ, Jones RM. Evaluating very high energy electron RBE from nanodosimetric pBR322 plasmid DNA damage Sci Rep. 2021 Feb 8;11(1):3341.

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