Caspase 9 Chromogenic Substrate

Description

Caspase 9 Chromogenic Substrate
Catalog number: B2011100
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 5 mg
Molecular Weight or Concentration: 674.7 g/mol
Supplied as: Lyophilized
Applications: molecular tool for various chemical, biochemical and immunological applications
Storage: -20 °C
Keywords: pNA
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Araya LE, Soni IV, Hardy JA, Julien O. Deorphanizing Caspase-3 and Caspase-9 Substrates In and Out of Apoptosis with Deep Substrate Profiling ACS Chem Biol. 2021 Nov 19;16(11):2280-2296.
2: Molnár T, Pallagi P, Tél B, Király R, Csoma E, Jenei V, Varga Z, Gogolák P, Odile Hueber A, Máté Z, Erdélyi F, Szabó G, Pettkó-Szandtner A, Bácsi A, Virág L, Maléth J, Koncz G. Caspase-9 acts as a regulator of necroptotic cell death FEBS J. 2021 Nov;288(22):6476-6491.
3: Chehade H, Fox A, Mor GG, Alvero AB. Determination of Caspase Activation by Western Blot Methods Mol Biol. 2021;2255:1-12.
4: Soni IV, Hardy JA. Caspase-9 Activation of Procaspase-3 but Not Procaspase-6 Is Based on the Local Context of Cleavage Site Motifs and on Sequence Biochemistry. 2021 Sep 21;60(37):2824-2835.
5: Huber KL, Serrano BP, Hardy JA. Caspase-9 CARD : core domain interactions require a properly formed active site Biochem J. 2018 Mar 29;475(6):1177-1196.
6: Serrano BP, Hardy JA. Phosphorylation by protein kinase A disassembles the caspase-9 core Cell Death Differ. 2018 Jun;25(6):1025-1039.
7: Han J, Goldstein LA, Hou W, Watkins SC, Rabinowich H. Involvement of CASP9 (caspase 9) in IGF2R/CI-MPR endosomal transport Autophagy. 2021 Jun;17(6):1393-1409.
8: Long HZ, Cheng Y, Zhou ZW, Luo HY, Wen DD, Gao LC. PI3K/AKT Signal Pathway: A Target of Natural Products in the Prevention and Treatment of Alzheimer’s Disease and Parkinson’s Disease Front Pharmacol. 2021 Apr 15;12:648636.
9: Serrano BP, Szydlo HS, Alfandari D, Hardy JA. Active site-adjacent phosphorylation at Tyr-397 by c-Abl kinase inactivates caspase-9 J Biol Chem. 2017 Dec 29;292(52):21352-21365.
10: Sangawa A, Shintani M, Yamao N, Kamoshida S. Phosphorylation status of Akt and caspase-9 in gastric and colorectal carcinomas Int J Clin Exp Pathol. 2014 May 15;7(6):3312-7. eCollection 2014.

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