ω-Conotoxin MVIIA

Product Description

ω-Conotoxin MVIIA
Catalog number: MDP0660
CAS Number: 219486-69-8
Sequence: Cys-Lys-Gly-Lys-Gly-Ala-Lys-Cys-Ser-Arg-Leu-Met-Tyr-Asp-Cys-Cys-Thr-Gly-Ser-Cys-Arg-Ser-Gly-Lys-Cys-NH2 (Reported disulfide bonds between Cys1-Cys16, Cys8-Cys20, and Cys15-Cys25)
Amount: 500 ug
Molecular Weight: 2638.8 g/mol
Supplied as: Powder
Applications: molecular tool for various biochemical applications
Storage: -20 °C
WARNING: For in vitro Research Use Only. NOT for use on humans or animals.
Grade: Biotechnology grade. All products are highly pure.

References:
1: Wie CS, Derian A. Ziconotide 2022 Jul 19. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan–.
2: Nonopioid drugs for pain Med Lett Drugs Ther. 2022 Mar 7;64(1645):33-40.
3: Gao S, Yao X, Yan N. Structure of human Ca(v)2.2 channel blocked by the painkiller ziconotide Nature. 2021 Aug;596(7870):143-147.
4: Deer TR, Pope JE, Hanes MC, McDowell GC. Intrathecal Therapy for Chronic Pain: A Review of Morphine and Ziconotide as Firstline Options Pain Med. 2019 Apr 1;20(4):784-798.
5: Yu S, Li Y, Chen J, Zhang Y, Tao X, Dai Q, Wang Y, Li S, Dong M. TAT-Modified ω-Conotoxin MVIIA for Crossing the Blood-Brain Barrier Mar Drugs. 2019 May 12;17(5):286.
6: Ziconotide 2023 May 15. Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006–.
7: Wang F, Chen G, Zhu Y, Guo Z, Zheng S, Zhan J. Development of antibody-based assays for omega-conotoxin MVIIA J Biochem Biophys Methods. 2006 Apr 30;67(1):49-56.
8: Viswanath O, Urits I, Burns J, Charipova K, Gress K, McNally A, Urman RD, Welschmeyer A, Berger AA, Kassem H, Sanchez MG, Kaye AD, Eubanks TN, Cornett EM, Ngo AL. Central Neuropathic Mechanisms in Pain Signaling Pathways: Current Evidence and Recommendations Adv Ther. 2020 May;37(5):1946-1959.
9: Yang Y, Ma Y, Li H, Wang S, Zhuang Z. Preparation and identification of monoclonal antibodies against ω-conotoxin MVIIA Monoclon Antib Immunodiagn Immunother. 2014 Aug;33(4):254-60.
10: Wang R, Zhong Y, Wang J, Yang H, Yuan J, Wang S. Development of an ic-ELISA and immunochromatographic strip based on IgG antibody for detection of ω-conotoxin MVIIA J Hazard Mater. 2019 Oct 15;378:120510.

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