(2-hydroxypropyl)-gamma-cyclodextrin Solution 10%


Catalog Number: K1010005E (25 mL)
(2-hydroxypropyl)-gamma-cyclodextrin Solution 10% (w/v) is a highly pure solution of cyclic hydroxylated dextrin of type Gamma. This product has been used as versatile tools in molecular assemblies, enhancement of solubility and organic synthesis. It has also been used in a wide array of other biochemical and immunological applications. Custom bulk amounts of this product are available upon request.

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(2-hydroxypropyl)-gamma-cyclodextrin Solution 10% (w/v)
Catalog number: K1010005E
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 25 mL
Molecular Weight or Concentration: 10% (w/v)
Supplied as: Solution
Applications: versatile tools in molecular assemblies, enhancement of solubility and organic synthesis
Storage: 2-8C
Keywords: (2-Hydroxypropyl)-γ-cyclodextrin, (2-Hydroxypropyl)-g-cyclodextrin, HGC
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

1: Singhal A, Krystofiak ES, Jerome WG, Song B. 2-Hydroxypropyl-gamma-
cyclodextrin overcomes NPC1 deficiency by enhancing lysosome-ER association and
autophagy. Sci Rep. 2020 May 26;10(1):8663.

2: Sursyakova VV, Levdansky VA, Rubaylo AI. Strong complexation of water-soluble
betulin derivatives with (2-hydroxypropyl)-γ-cyclodextrin studied by affinity
capillary electrophoresis. Electrophoresis. 2020 Jan;41(1-2):112-115. d

3: Hoque S, Kondo Y, Sakata N, Yamada Y, Fukaura M, Higashi T, Motoyama K, Arima
H, Higaki K, Hayashi A, Komiya T, Ishitsuka Y, Irie T. Differential Effects of
2-Hydroxypropyl-Cyclodextrins on Lipid Accumulation in Npc1-Null Cells.
Int J Mol Sci. 2020 Jan 30;21(3):898.

4: Sursyakova VV, Levdansky VA, Rubaylo AI. Determination of binding constants
for strong complexation by affinity capillary electrophoresis: the example of
complexes of ester betulin derivatives with (2-hydroxypropyl)-γ-cyclodextrin.
Anal Bioanal Chem. 2020 Sep;412(23):5615-5625.

5: Sursyakova VV, Levdansky VA, Rubaylo AI. Thermodynamic parameters for the
complexation of water-insoluble betulin derivatives with
(2-hydroxypropyl)-γ-cyclodextrin determined by phase-solubility technique
combined with capillary zone electrophoresis. Electrophoresis. 2019

6: Wathoni N, Motoyama K, Higashi T, Okajima M, Kaneko T, Arima H. Enhancement
of curcumin wound healing ability by complexation with 2-hydroxypropyl-γ-
cyclodextrin in sacran hydrogel film. Int J Biol Macromol. 2017 May;98:268-276.

7: Blum W, Aichholz R, Ramstein P, Fetz A, Raschdorf F. Determination of
2-hydroxypropyl-gamma-cyclodextrin in plasma of cynomolgus monkeys after oral
administration by gas chromatography-mass spectrometry. J Chromatogr B Biomed
Sci Appl. 1998 Dec 11;720(1-2):171-8.

8: Huang H, Yu H, Tang G, Wang Q, Li J. Low molecular weight polyethylenimine
cross-linked by 2-hydroxypropyl-gamma-cyclodextrin coupled to peptide targeting
HER2 as a gene delivery vector. Biomaterials. 2010 Mar;31(7):1830-8.

9: Macedo OF, Andrade GR, Conegero LS, Barreto LS, Costa NB Jr, Gimenez IF,
Almeida LE, Kubota D. Physicochemical study and characterization of the
trimethoprim/2-hydroxypropyl-γ-cyclodextrin inclusion complex. Spectrochim Acta
A Mol Biomol Spectrosc. 2012 Feb;86:101-6.
10: Huang H, Tang G, Wang Q, Li D, Shen F, Zhou J, Yu H. Two novel non-viral
gene delivery vectors: low molecular weight polyethylenimine cross-linked by
(2-hydroxypropyl)-beta-cyclodextrin or (2-hydroxypropyl)-gamma-cyclodextrin.
Chem Commun (Camb). 2006 Jun 14;(22):2382-4.

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