(2-hydroxypropyl)-beta-cyclodextrin Solution 10% (w/v)


Catalog Number: K1010005D (25 mL)
(2-hydroxypropyl)-beta-cyclodextrin Solution 10% (w/v) is a highly pure solution of cyclic hydroxylated dextrin of type Beta. This product has been used as versatile tools in molecular assemblies, enhancement of solubility and organic synthesis. It has also been used in a wide array of other biochemical and immunological applications. Custom bulk amounts of this product are available upon request.

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(2-hydroxypropyl)-beta-cyclodextrin Solution 10% (w/v)
Catalog number: K1010005D
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 25 mL
Molecular Weight or Concentration: 10% (w/v)
Supplied as: Solution
Applications: versatile tools in molecular assemblies, enhancement of solubility and organic synthesis
Storage: 2-8C
Keywords: (2-hydroxypropyl)-b-cyclodextrin, (2-hydroxypropyl)-β-cyclodextrin
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

1: Sun H, Zong H, Wu G. 2‑Hydroxypropyl‑β‑cyclodextrin blocks autophagy flux and
triggers caspase‑8‑mediated apoptotic cascades in HepG2 cells. Mol Med Rep. 2020

2: Kao ML, Stellar S, Solon E, Lordi A, Kasica N, Swain G, Bagel JH, Gurda BL,
Vite CH. Pharmacokinetics and distribution of 2-hydroxypropyl-β-cyclodextrin
following a single intrathecal dose to cats. J Inherit Metab Dis. 2020

3: Leonis G, Christodoulou E, Ntountaniotis D, Chatziathanasiadou MV,
Mavromoustakos T, Naziris N, Chountoulesi M, Demetzos C, Valsami G, Damalas DE,
Tzakos AG, Thomaidis NS, Karageorgos V, Liapakis G. Antihypertensive activity
and molecular interactions of irbesartan in complex with 2-hydroxypropyl-β-
cyclodextrin. Chem Biol Drug Des. 2020 Jul;96(1):668-683.

4: Ding Y, Pang Y, Vara Prasad CVNS, Wang B. Formation of inclusion complex of
enrofloxacin with 2-hydroxypropyl-β-cyclodextrin. Drug Deliv. 2020

5: Pons-Faudoa FP, Sizovs A, Di Trani N, Paez-Mayorga J, Bruno G, Rhudy J,
Manohar M, Gwenden K, Martini C, Chua CYX, Varchi G, Marzinke MA, Grattoni A.
2-Hydroxypropyl-β-cyclodextrin-enhanced pharmacokinetics of cabotegravir from a
nanofluidic implant for HIV pre-exposure prophylaxis. J Control Release. 2019
Jul 28;306:89-96.

6: Stappaerts J, Berben P, Cevik I, Augustijns P. The effect of 2-hydroxypropyl-
β-cyclodextrin on the intestinal permeation through mucus. Eur J Pharm Sci. 2018
Mar 1;114:238-244.

7: Liu X, Ding D, Chen GD, Li L, Jiang H, Salvi R. 2-Hydroxypropyl-β-
cyclodextrin Ototoxicity in Adult Rats: Rapid Onset and Massive Destruction of
Both Inner and Outer Hair Cells Above a Critical Dose. Neurotox Res. 2020

8: Yu SC, Chen TC, Hou YT, Wan L, Tsai FJ, Tsai Y. β-Sitosterol-2-hydroxypropyl-
β-cyclodextrin inclusion complex: Characterization and inhibitory effect on
adipogenesis in 3T3-L1 pre-adipocytes. Steroids. 2018 Dec;140:196-201.

9: Burga-Sánchez J, Ferreira LEN, Volpato MC, Cabeça LF, Braga M, Fraceto LF, de
Paula E, Groppo FC. Physicochemical characterization and cytotoxicity of
articaine-2-hydroxypropyl-β-cyclodextrin inclusion complex. Naunyn Schmiedebergs
Arch Pharmacol. 2020 Jul;393(7):1313-1323.
10: Han D, Han Z, Liu L, Wang Y, Xin S, Zhang H, Yu Z. Solubility Enhancement of
Myricetin by Inclusion Complexation with
Heptakis-O-(2-Hydroxypropyl)-β-Cyclodextrin: A Joint Experimental and
Theoretical Study. Int J Mol Sci. 2020 Jan 24;21(3):766.

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